HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION MASS SPECTROMETRY FOR THERAPEUTIC DRUG MONITORING OF METFORMIN AND ROSUVASTATIN IN HUMAN PLASMA

Hydrophilic Interaction Liquid Chromatography-Electrospray Ionization Mass Spectrometry for Therapeutic Drug Monitoring of Metformin and Rosuvastatin in Human Plasma

In this work a hydrophilic interaction liquid chromatography/positive ion electrospray mass spectrometric assay (HILIC/ESI-MS) has been developed and fully validated for the quantitation of metformin and Salt and Pepper Pots rosuvastatin in human plasma.Sample preparation involved the use of 100 μL of human plasma, following protein precipitatio

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